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  • Inclusion Body Myositis: Variability and Clinical Subsets

    Inclusion body myositis (IBM) is a progressive myopathy characterized by prominent finger flexor and quadriceps involvement. Black patients with IBM have more prominent proximal weakness, in addition to finger flexion and quadriceps weakness. Female patients have less prominent finger flexion and quadriceps weakness and slower progression, whereas younger patients had a greater delay in diagnosis. There are variability and distinct clinical subsets among IBM patients, which can have implications in terms of timely diagnosis and possibly response to treatments.

  • The Neural Pathways of Pain Treatment Response in Small-Fiber Neuropathy

    Pain in peripheral neuropathy, referred to as neuropathic pain, is thought to result from overexpression of pain receptors, regeneration of hypersensitive nerve sprouts, and denervation hypersensitivity of neurons in the sensory ganglia. Additionally, activation of the pain pathways appears to induce secondary structural and functional changes in the brain that contribute to pain perception, persistence, and response.

  • Focused Ultrasound Ablation of the Subthalamic Nucleus for Parkinson’s Disease Tremor

    This paper demonstrated the long-term efficacy and safety of unilateral magnetic resonance imaging-guided high-frequency ultrasound subthalamotomy for Parkinson’s disease patients with motor fluctuations and dyskinesia three years after the procedure.

  • Role of the Hypothalamus in Migraine and Cluster Headaches

    The hypothalamus plays a regulatory role in both migraine and cluster headaches. However, the two headache types have distinctive clinical features, characteristic areas of resting state functional connectivity on magnetic resonance imaging, and different genetic chronobiological associations.

  • Drug-Resistant Candida auris Now in Half of U.S. States

    The seemingly inexorable rise and spread of drug-resistant Candida auris continues in the United States. The Centers for Disease Control and Prevention reported that clinical infections increased 59% in 2020, then nearly doubled in 2021 with a 95% jump.

  • Fungi: Pop Culture Darling a Future Pandemic Threat

    Raising public awareness, fungi are having something of a pop culture moment in podcasts, videos, and a popular post-apocalyptic television series.

  • CLABSI Collaboration Cuts Infection Rates 70%

    Infection preventionists and colleagues from quality and education spearheaded a hospital-wide team and engaged all staff to dramatically reduce central line-associated bloodstream infections by 70%.

  • SHEA, APIC Update CLABSI Guidelines

    Chlorhexidine-containing dressings are now considered an “essential practice” for the prevention of central line-associated bloodstream infections in patients older than age 2 months, according to a consensus paper by five medical societies and associations.

  • Aftermath: COVID Catastrophe in LTC Spurs Calls for Change

    As of March 26, 2023, there were 165,347 nursing home resident deaths and 3,067 staff deaths caused by SARS-CoV-2 reported by the Centers for Medicare and Medicaid Services.

  • CDC: Be Wary of Travelers from African Outbreaks

    Marburg virus has caused outbreaks in two African nations, and infection preventionists should be aware of travel history for incoming patients with hemorrhagic fever symptoms, the Centers for Disease Control and Prevention warned.